Malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
L-Malate + NAD+ ⇌ oxaloacetate + NADH + H+
Converts Malate NAD+ into Oxaloacetate NADH H+
› Notes
Required cofactor: NAD+. Although the standard free-energy change is unfavorable, the reaction proceeds in vivo because citrate synthase rapidly consumes oxaloacetate; it is reversible and regenerates the acceptor required for the next turn.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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