Cytosolic malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Malate + NAD+ ↔ oxaloacetate + NADH + H+
Converts Malate NAD+ into Oxaloacetate NADH H+
› Notes
Cytosolic malate dehydrogenase regenerates oxaloacetate and produces cytosolic NADH. The malate transport step itself is carrier-mediated rather than enzymatic; the two dehydrogenase reactions constitute the redox shuttle.
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Oxaloacetate + NADH + H+ → malate + NAD+
Converts Oxaloacetate NADH H+ into Malate NAD+
› Notes
Cytosolic malate dehydrogenase reduces oxaloacetate, using NADH. Malate may return to mitochondria or be used to generate NADPH.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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