Lactate dehydrogenase (LDH)
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Pyruvate + NADH + H+ ⇌ lactate + NAD+
Converts Pyruvate NADH H+ into Lactate NAD+
› Notes
Required cofactor: NADH/NAD+. This reversible reaction is the defining fermentation step; it produces no additional ATP but is indispensable for maintaining the NAD+ required by glyceraldehyde-3-phosphate dehydrogenase when cytosolic NADH cannot be reoxidized sufficiently through mitochondrial shuttles and the ETC.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Anaerobic Glycolysis / Lactic Acid Fermentation
Listed there as: Lactate dehydrogenase
Pyruvate and NADH availability; high cytosolic NADH/NAD+ ratio favors lactate formation
Product/thermodynamic limitation by high lactate and NAD+; no primary allosteric inhibitor of central control
No dominant acute direct hormonal switch; hormonal changes in glycolytic flux and perfusion indirectly affect lactate production
Recent literature
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