FAD-dependent dehydrogenase step (BCAA branch)
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Valine-derived isobutyryl-CoA → methacrylyl-CoA → 3-hydroxyisobutyryl-CoA → methylmalonate semialdehyde → propionyl-CoA → succinyl-CoA
Converts Valine-derived isobutyryl-CoA into Methacrylyl-CoA
› Notes
FAD-dependent dehydrogenation, hydration, hydrolysis, NAD⁺-dependent oxidation, and the biotin- and adenosylcobalamin-dependent propionyl-CoA pathway yield succinyl-CoA. Therefore valine is glucogenic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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