D-beta-hydroxybutyrate dehydrogenase (BDH1)
Cofactors used
What it does, reaction by reaction
Ketogenesis Lipid Metabolism · Liver mitochondrial matrix
Acetoacetate + NADH + H+ ⇌ D-β-hydroxybutyrate + NAD+
Converts Acetoacetate NADH H+ into D-beta-hydroxybutyrate NAD+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase interconverts the two principal ketone bodies. The mitochondrial NADH/NAD+ ratio determines their ratio: high NADH generated by β-oxidation favors D-β-hydroxybutyrate.
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
D-β-hydroxybutyrate + NAD+ → acetoacetate + NADH + H+
Converts D-beta-hydroxybutyrate NAD+ into Acetoacetate NADH H+
› Notes
Mitochondrial D-β-hydroxybutyrate dehydrogenase oxidizes D-β-hydroxybutyrate to acetoacetate. This produces one NADH, and the reaction direction in extrahepatic tissue is favored by the local mitochondrial redox state.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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