EC 1.4.3.4 MAOA/MAOB 1 reactions
MAOI + tyramine: hypertensive crisis
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
1 reactions
1 reactions
EC 2.3.1.5 NAT2 1 reactions
Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus
EC 1.14.13.39 NOS1-3 1 reactions
NO -> cGMP; nitrate and PDE5-inhibitor axis
1 reactions
1 reactions
1 reactions
EC 2.7.4.6 / 3.6.1.23 NME1 / DUT 1 reactions
EC 2.7.4.6 NME1 / NME2 1 reactions
1 reactions
EC 4.1.1.23 UMPS 1 reactions
Hereditary orotic aciduria (second UMP synthase domain)
EC 2.1.3.3 OTC 1 reactions
OTC deficiency (X-linked, commonest urea cycle defect): hyperammonaemia with HIGH orotic acid, low BUN
EC 2.4.2.10 UMPS 1 reactions
Hereditary orotic aciduria: megaloblastic anaemia unresponsive to B12/folate; treat with uridine
ABCB1 / ABCC1-3 1 reactions
EC 3.1.1.3 / 3.1.1.4 / 3.1.1.13 PNLIP / CLPS / PLA2G1B / CEL 1 reactions
Suppressed indirectly by corticosteroids (annexin/lipocortin)
EC 1.14.16.1 PAH 1 reactions
Phenylketonuria: musty odour, intellectual disability, hypopigmentation; BH4 defects cause malignant PKU
EC 2.1.1.28 PNMT 1 reactions
1 reactions
EC 2.1.1.17 PEMT 1 reactions