Pancreatic lipase/colipase, phospholipase A2, cholesterol esterase (+ bile salts)
Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Dietary TAG, cholesteryl esters, and phospholipids → emulsified mixed micelles
Converts Triacylglycerol (TAG) Cholesteryl ester Phospholipid into Mixed micelle
› Notes
In the intestinal lumen, bile salts emulsify dietary lipids; pancreatic lipase with colipase hydrolyzes TAG predominantly to 2-monoacylglycerol plus fatty acids, phospholipase A2 hydrolyzes phospholipids, and cholesterol esterase hydrolyzes cholesteryl esters. This digestive stage is required for absorption but is not a lipoprotein-particle reaction; pancreatic lipase inhibition by orlistat reduces this flux.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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