OATP1B1/OATP1B3 uptake + ligandin binding (transport, not enzymatic)
What it does, reaction by reaction
Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut
Unconjugated bilirubin (albumin-bound) → hepatocyte-associated unconjugated bilirubin
Converts Unconjugated bilirubin into Hepatocyte-associated unconjugated bilirubin
› Notes
Hepatic sinusoidal uptake is carrier-mediated (not a covalent enzymatic conversion), followed by cytosolic binding to ligandin/GST proteins. Albumin-bound bilirubin cannot be filtered by the kidney and is not directly excreted in urine.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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