N-acetyltransferase (NAT1/NAT2)
Cofactors used
Clinical / pharmacological. Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus
What it does, reaction by reaction
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
Substrate + acetyl-CoA -> acetylated metabolite + CoA-SH
Converts Acetyl-CoA into Acetylated metabolite CoA-SH
› Notes
NAT2 slow-acetylator status predisposes to isoniazid neuropathy and hydralazine-induced lupus.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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