OMP decarboxylase (UMP synthase domain 2)
Clinical / pharmacological. Hereditary orotic aciduria (second UMP synthase domain)
What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
OMP → UMP
Converts Orotidine 5'-monophosphate (OMP) into UMP
› Notes
OMP decarboxylase, the second UMP synthase activity, catalyzes OMP → UMP + CO2. This is one of the most proficient known enzymatic decarboxylations and commits the incorporated ribose nucleotide to the uracil nucleotide pool.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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