P-glycoprotein (MDR1/ABCB1); MRP (ABCC) transporters
Cofactors used
What it does, reaction by reaction
Phase III - Efflux & Excretion Xenobiotic & Drug Metabolism · Plasma membrane (ABC transporters)
Conjugated metabolite (intracellular) + ATP -> extracellular metabolite + ADP + Pi
Converts Conjugated metabolite (intracellular) ATP into Extracellular metabolite ADP Pi
› Notes
ATP-binding-cassette efflux at the canalicular, intestinal and blood-brain barrier membranes; a major source of drug interactions and of tumour multidrug resistance.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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