Enzymes & cofactors

Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.

Enzymes Cofactor terms Vitamins & minerals

Cofactor / coenzyme

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Malate dehydrogenase

EC 1.1.1.37 MDH2 1 reactions

Malate-alpha-ketoglutarate antiporter (SLC25A11)

SLC25A11 1 reactions

Maleylacetoacetate isomerase

1 reactions

Methenyl-THF cyclohydrolase (MTHFD1)

1 reactions

Methionine adenosyltransferase (MAT)

1 reactions

Methylene-THF dehydrogenase (MTHFD1)

EC 1.5.1.5 MTHFD1 1 reactions

Methylenetetrahydrofolate reductase (MTHFR)

EC 1.5.1.20 MTHFR 1 reactions

MTHFR variants: hyperhomocysteinaemia

Methylmalonyl-CoA epimerase (racemase)

EC 5.1.99.1 MCEE 1 reactions

Methylmalonyl-CoA mutase (MMUT)

EC 5.4.99.2 MMUT 1 reactions

Methylmalonic acidaemia; adenosylcobalamin (B12)-dependent

Mevalonate kinase

EC 2.7.1.36 MVK 1 reactions

Mitochondrial ALA synthase (ALAS) RL

EC 2.3.1.37 ALAS1/ALAS2 1 reactions

ALAS2 defects: X-linked sideroblastic anaemia (B6-responsive)

Mitochondrial aspartate aminotransferase (GOT2)

1 reactions

Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2)

EC 1.1.5.3 GPD2 1 reactions

Mitochondrial HMG-CoA synthase (HMGCS2) RL

EC 2.3.3.10 HMGCS2 1 reactions

Rate-limiting for ketogenesis; induced by fasting/PPAR-alpha

Mitochondrial malate dehydrogenase

EC 1.1.1.37 MDH2 1 reactions

Mitochondrial malate dehydrogenase (MDH2)

EC 1.1.1.37 MDH2 1 reactions

Mitochondrial pyruvate carboxylase

EC 6.4.1.1 PC 1 reactions

PC deficiency: lactic acidosis, hypoglycaemia, neurological disease

Mobile carriers: ubiquinone (CoQ) and cytochrome c

1 reactions

Monoacylglycerol acyltransferase + DGAT + ACAT2 (enterocyte)

1 reactions

Monoacylglycerol lipase (MGL; MGLL)

1 reactions