Mitochondrial malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Oxaloacetate + NADH + H+ ↔ malate + NAD+
Converts Oxaloacetate NADH H+ into Malate NAD+
› Notes
Mitochondrial malate dehydrogenase reduces oxaloacetate to malate using NADH when oxaloacetate must be exported and cytosolic NADH is needed. Oxaloacetate cannot directly cross the inner mitochondrial membrane; malate is transported to the cytosol and reoxidized by cytosolic malate dehydrogenase in the next step. When gluconeogenic carbon enters as lactate, cytosolic lactate dehydrogenase supplies NADH, and mitochondrial PEP formation/export can be used instead.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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