What it does, reaction by reaction
1 reactions
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
step 5
Irreversible
Orotate → orotidine 5′-monophosphate (OMP)
Converts Orotate into Orotidine 5'-monophosphate (OMP)
› Notes
Orotate phosphoribosyltransferase (OPRT), the first activity of bifunctional UMP synthase, catalyzes orotate + PRPP → OMP + PPi. Mg2+ is required, and PPi hydrolysis makes the step effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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