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Enzymes & cofactors

Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.

Enzymes Cofactor terms Vitamins & minerals

Cofactors and coenzymes in use

Click any term to filter the enzyme list to reactions that use it

53 terms

H2O

66
steps

ATP

63
steps

Pi

39
steps

Mg2+

Magnesium

33
steps

NADPH

B3 (Niacin)

33
steps

NAD+

B3 (Niacin)

30
steps

NADH

B3 (Niacin)

26
steps

CoA-SH

B5 (Pantothenic acid)

24
steps

O2

24
steps

PLP (B6)

B6 (Pyridoxine)

22
steps

NADP+

B3 (Niacin)

20
steps

FAD

B2 (Riboflavin)

19
steps

THF (folate)

B9 (Folate)

18
steps

PPi

17
steps

FADH2

9
steps

Heme/cytochrome

Iron

9
steps

Bicarbonate/CO2

8
steps

Fe2+

Iron

8
steps

TPP (B1)

B1 (Thiamine)

8
steps

ACP

7
steps

Lipoamide

7
steps

SAM

7
steps

Biotin (B7)

B7 (Biotin)

6
steps

PRPP

6
steps

Cobalamin (B12)

B12 (Cobalamin)

5
steps

Fe-S cluster

Iron

5
steps

Mn2+

5
steps

Ubiquinone (CoQ)

5
steps

BH4

4
steps

GTP

4
steps

heme

4
steps

UTP

4
steps

Acetyl-CoA

3
steps

Ca2+

3
steps

Carnitine

3
steps

Glutathione

3
steps

CTP

2
steps

Cu

Copper

2
steps

FMN

B2 (Riboflavin)

2
steps

K+

2
steps

NAD(P)H

2
steps

UDP-glucuronic acid

2
steps

Ascorbate (vit C)

C (Ascorbate)

1
steps

CO2

1
steps

CYP reductase

1
steps

Dipyrromethane

1
steps

Fe

1
steps

GSH

1
steps

PAPS

1
steps

Selenium

1
steps

Thioredoxin

1
steps

UDP-glucose

1
steps

Vitamin K hydroquinone

1
steps