Glutamate
Reactions involving Glutamate
Every recorded step where this molecule takes part
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Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
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consumed gamma-Glutamylcysteine synthetase (GCL) Glutathione Metabolism (gamma-Glutamyl Cy… ST-0336 rate-limiting
L-Glutamate + L-cysteine + ATP -> gamma-glutamylcysteine + ADP + Pi
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L-Glutamate -> GABA + CO2
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L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
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consumed Glutamate-aspartate antiporter (citrin/aralar, SLC25A13/12) Malate-Aspartate Shuttle ST-0357
Aspartate(matrix) + glutamate(cytosol) -> aspartate(cytosol) + glutamate(matrix)
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Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
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produced Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal) Amino Acid Catabolism Overview (glucogeni… ST-0146
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
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Leucine/isoleucine/valine + α-ketoglutarate ⇌ their respective branched-chain α-keto acids + glutamate
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L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
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L-glutamine + H₂O → L-glutamate + NH₄⁺
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E-PMP + α-ketoglutarate → E-PLP + L-glutamate
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L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Glutamate-glutamine axis in pancreatic β-cells: mechanistic insights and therapeutic prospects in diabetes and its complications.
Olatunde A, Disina HB, Eyitayo AR, Jahun AM, Tiamiyu MT, Baba RM, Mshelia P, Johnson TO. · 2026-07-30
unreviewed -
2
Metabolic disruption associated with e-cigarette vaping and secondhand exposure: Urinary metabolomics evidence from a Thai population.
Tajai P, Sawatdikun S, Srisopa T, Konguthaithip G, Parinyarux P, Ditsawanon P, Charoensook P. · 2026-07-11
unreviewed -
3
Impact of chronic dietary aflatoxin B1 intake on rumen fermentation, hepatic health, oxidative stress, inflammation, and glucose-lipid metabolism in fat-tailed ewes.
Ider N, Khalilvandi-Behroozyar H, Ahmadpour A, Farhangpajouh F, Sahebi-Ala M, Chen Y, Hosseini Ghaffari M. · 2026-07-08
unreviewed -
4
mTORC2-Na<sub>v</sub>1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model.
Dvorak NM, Noebels JL. · 2026-06-22
open access unreviewed -
5
Metabolic profile association with white matter hyperintensity in patients with mild cognitive impairment.
Ariaei A, Zamiri R, Ghasemi A, Rezayani B, Rezayani S, Ezatpour A, Farshidi N, Sheikhi EA, Roghanian A, Alzhe… · 2026-06-09
open access unreviewed -
6
Ditan Decoction alleviates glutamate excitotoxicity in an Aβ-induced Alzheimer's disease-like model through the regulation of ERBB2/PI3K/AKT signaling pathway.
Ren L, Liu S, Sun X, Zhang Y, Wang P, Liu L, Chen LL. · 2026-06-19
unreviewed -
7
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
8
mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection.
Ye Q, Tang X, Cai H, Yuan M, Ba X, Tian Y, Chen J, Wang X, Xiang R. · 2026-06-19
open access unreviewed -
9
Bacterial microbiome and flavor metabolome shifts in traditional Hinggan league sauerkraut fermentation.
Yang Y, Zhang H, Shuang Q, Xia YN. · 2026-06-02
open access unreviewed -
10
A cell-free system for 1,6-hexanediamine synthesis using bulk chemical caprolactam as the feedstock.
Liu R, Li C, Zhang Y, Li G, Deng Y. · 2026-06-05
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.