Alanine aminotransferase (ALT / GPT)
Cofactors used
What it does, reaction by reaction
Transamination Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
Converts Alanine Alpha-ketoglutarate into Pyruvate Glutamate
› Notes
Alanine aminotransferase (ALT/GPT) catalyzes this PLP-dependent, reversible reaction. In the glucose–alanine cycle, muscle exports alanine and liver converts it to pyruvate for gluconeogenesis while retaining the nitrogen as glutamate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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