Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal)
Cofactors used
Clinical / pharmacological. Activating mutations: hyperinsulinism-hyperammonaemia syndrome
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
Converts Alpha-ketoglutarate into Glutamate
› Notes
A PLP-dependent aminotransferase commonly initiates catabolism of amino acids whose nitrogen is handled by transamination. The reaction is reversible; glutamate subsequently supplies ammonia through GDH or supplies aspartate for urea synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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