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PW-056 Carbohydrate Metabolism Inter-organ cycle unreviewed

Glucose-Alanine Cycle

Muscle pyruvate + amino nitrogen Hepatic glucose + urea nitrogen
Compartment
Cytosol
Main tissue
Muscle <-> liver
Rate-limiting
Not flagged in the source
Steps
2

Reaction steps

In source order, 2 total

showing 1–2
  1. 1

    Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)

    Alanine aminotransferase (ALT/GPT) 2.6.1.2 ST-0381 Reversible PLP (B6)
    In Pyruvate Glutamate
    Out Alanine Alpha-ketoglutarate
    › Notes

    Exports both muscle nitrogen and carbon in a non-toxic form.

  2. 2

    Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)

    Alanine aminotransferase (ALT/GPT) 2.6.1.2 ST-0382 Reversible PLP (B6)
    In Alanine Alpha-ketoglutarate
    Out Pyruvate Glutamate
    › Notes

    Pyruvate enters gluconeogenesis; the nitrogen passes through glutamate to the urea cycle.

Showing all 2 steps.

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