Alanine aminotransferase (ALT/GPT)
Cofactors used
What it does, reaction by reaction
Glucose-Alanine Cycle Carbohydrate Metabolism · Cytosol
Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
Converts Pyruvate Glutamate into Alanine Alpha-ketoglutarate
› Notes
Exports both muscle nitrogen and carbon in a non-toxic form.
Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
Converts Alanine Alpha-ketoglutarate into Pyruvate Glutamate
› Notes
Pyruvate enters gluconeogenesis; the nitrogen passes through glutamate to the urea cycle.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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