What it does, reaction by reaction
Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix
L-glutamine + H₂O → L-glutamate + NH₄⁺
Converts Glutamine H2O into Glutamate NH4+
› Notes
Glutaminase hydrolyzes the amide nitrogen of glutamine in mitochondria; it requires water but no redox cofactor. This irreversible hydrolytic deamidation is not itself oxidative deamination, but it is a major upstream source of mitochondrial glutamate and ammonia in liver, kidney, intestine, and brain.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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