unreviewed

Tyrosine aminotransferase (TAT)

1 reactions · 1 pathways

Cofactors used

PLP (B6) · B6 (Pyridoxine)

What it does, reaction by reaction

1 reactions

Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 10 Reversible

L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate

Converts Tyrosine Alpha-ketoglutarate into 4-Hydroxyphenylpyruvate Glutamate

› Notes

Tyrosine aminotransferase catalyzes this PLP-dependent, reversible reaction. Its activity is induced in liver by glucocorticoids during catabolic states.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples)

Listed there as: Tyrosine aminotransferase

Accelerated by

Tyrosine availability

Inhibited by

Product accumulation

Hormonal control

Glucocorticoids induce hepatic enzyme expression; insulin has opposing fed-state effects

Recent literature

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