Junction / hub Pathway metabolite unreviewed

Pyruvate

Pathways

Reactions involving Pyruvate

Every recorded step where this molecule takes part

All 12 Consumed 5 Produced 7

produced Lactate dehydrogenase (LDHB) + gluconeogenic enzymes Cori Cycle (lactate shuttle) ST-0380

Lactate -> pyruvate -> glucose (liver, 6 ATP equivalents)
produced Alanine aminotransferase (ALT/GPT) Glucose-Alanine Cycle ST-0382

Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
produced Pyruvate kinase Glycolysis ST-0010

Phosphoenolpyruvate + ADP → pyruvate + ATP
produced Cytosolic, NADP+-dependent malic enzyme Fatty Acid Synthesis (De Novo Lipogenesis) ST-0063

Malate + NADP+ → pyruvate + CO2 + NADPH + H+
produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147

Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
produced Alanine aminotransferase (ALT / GPT) Transamination ST-0135

L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
produced Pyruvate kinase Anaerobic Glycolysis / Lactic Acid Fermen… ST-0297

Phosphoenolpyruvate + ADP → pyruvate + ATP

Showing all 7 reactions.

Pathway junctions through this molecule

Produced in one pathway, consumed in another

33 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Gluconeogenesis	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Glucose-Alanine Cycle	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Gluconeogenesis	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Glucose-Alanine Cycle	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Pyruvate Dehydrogenase Complex (Link Reacti…	within category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Cori Cycle (lactate shuttle)	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Cori Cycle (lactate shuttle)	→	Gluconeogenesis	within category
Cori Cycle (lactate shuttle)	→	Glucose-Alanine Cycle	within category
Cori Cycle (lactate shuttle)	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Cori Cycle (lactate shuttle)	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Gluconeogenesis	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Glucose-Alanine Cycle	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Glucose-Alanine Cycle	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Glucose-Alanine Cycle	→	Gluconeogenesis	within category
Glucose-Alanine Cycle	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Glucose-Alanine Cycle	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Glycolysis	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Glycolysis	→	Gluconeogenesis	within category
Glycolysis	→	Glucose-Alanine Cycle	within category
Glycolysis	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Glycolysis	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Transamination	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Transamination	→	Gluconeogenesis	cross-category
Transamination	→	Glucose-Alanine Cycle	cross-category
Transamination	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Transamination	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category

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