Alpha-ketoglutarate
Reactions involving Alpha-ketoglutarate
Every recorded step where this molecule takes part
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Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
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consumed Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal) Amino Acid Catabolism Overview (glucogeni… ST-0146
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
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Leucine/isoleucine/valine + α-ketoglutarate ⇌ their respective branched-chain α-keto acids + glutamate
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L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
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E-PMP + α-ketoglutarate → E-PLP + L-glutamate
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L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
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L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
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Branched-chain amino acid + α-ketoglutarate ⇌ branched-chain α-keto acid + L-glutamate
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Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+
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Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
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produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147
Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
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L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
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