Alpha-ketoglutarate
Reactions involving Alpha-ketoglutarate
Every recorded step where this molecule takes part
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Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
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consumed Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal) Amino Acid Catabolism Overview (glucogeni… ST-0146
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
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Leucine/isoleucine/valine + α-ketoglutarate ⇌ their respective branched-chain α-keto acids + glutamate
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L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
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E-PMP + α-ketoglutarate → E-PLP + L-glutamate
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L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
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L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
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Branched-chain amino acid + α-ketoglutarate ⇌ branched-chain α-keto acid + L-glutamate
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Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+
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Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
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produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147
Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
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L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
FTO-mediated m<sup>6</sup>A demethylation of BCL6 promotes gastric cancer progression by suppressing ferroptosis.
Wang Y, Fan F, Zhan Z, Yu C, Chen S. · 2026-06-10
open access unreviewed -
2
Metformin counteracts lipid accumulation and cell proliferation in hepatocellular carcinoma via regulating METTL3-mediated m<sup>6</sup>A methylation.
Qi Y, Chen C, Dai Y, Wang Z, Liu X, Guo C, Wang M, Hu Z, Di H. · 2026-05-03
unreviewed -
3
<b>Simulated</b> microgravity induces cerebral dysfunction by disturbing protective microbiota-metabolite-microglia signaling across the gut‒brain ax<b>is</b>.
Zhang B, Si Y, Liu Y, Wei J, Li M, Si D, Li H, Wang X, Han P, Wang W, Bao J, Cheng L, Lei Y, Ma H, Liu Y. · 2026-02-23
open access unreviewed -
4
Integrative spatiotemporal analysis uncovers an Fto-mediated epigenetic-metabolic axis governing myocardial ischemic injury.
Chen R, Wang X, Wang R, Zhang Z, Qin L, Liu Z, Lan H, Wu J, Liu S, Chen Z, Luan X, Li B, Li G, Chu X. · 2026-07-02
unreviewed -
5
NPM1 mutation promotes creatine anabolism by FTO-dependent m<sup>6</sup>A demethylation to drive macrophage M2 polarization in acute myeloid leukemia.
Wang JD, Liao CJ, Lei XX, Peng ZZ, Lin ZL, Liu JJ, Liu Q, Zhang L, Long ZJ. · 2026-05-29
unreviewed -
6
FTO alleviates chronic restraint stress-induced cognitive deficits and depressive-like behaviors via regulating PI3K/Akt signaling, autophagy, and synaptic plasticity.
Shen J, Zi Y, Xu Y, Zhu X, Shi L. · 2026-06-19
unreviewed -
7
Inaccurate interpretation of hypoxia signatures from transcriptomic analyses in neuro-oncology.
Simmons RK, Raut P, Younes ST, Gallo M. · 2026-06-17
open access unreviewed -
8
Attenuated FTO induces necroptosis of alveolar epithelium via the m<sup>6</sup>A/CYP1B1/ROS/MLKL axis to promote the aggravation of pulmonary emphysema.
Wu M, Wang W, Chen Z, Yang Y, Yan J, Cui Y, Huang P, Zhang F, Tu W, Chen W, Sun R, Zhou Y, Zhu L, Ran P. · 2026-05-27
open access unreviewed -
9
Sustainable production of glutaric acid in microbial cell factories: Current advances and future prospects.
Liu J, Mei D, Zhang XJ, Zhang WG, Zhu LB. · 2026-01-23
open access unreviewed -
10
Alpha-ketoglutarate ameliorates diabetes-associated skeletal muscle fibrosis by restoring TET2-dependent epigenetic remodeling in CD90 positive fibro-adipogenic progenitors.
Tong ZJ, Li YH, Song M, Sheng YN, Wu YZ, Shang YY, Hu BA, Lu B, Zhu P, Wang GQ, Zhan HJ, Han L, Zhang W, Wang… · 2026-08-10
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.