Alpha-ketoglutarate
Reactions involving Alpha-ketoglutarate
Every recorded step where this molecule takes part
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Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
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consumed Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal) Amino Acid Catabolism Overview (glucogeni… ST-0146
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
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Leucine/isoleucine/valine + α-ketoglutarate ⇌ their respective branched-chain α-keto acids + glutamate
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L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
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E-PMP + α-ketoglutarate → E-PLP + L-glutamate
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L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
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L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
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Branched-chain amino acid + α-ketoglutarate ⇌ branched-chain α-keto acid + L-glutamate
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Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+
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Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
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produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147
Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
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L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Combining automated kinetic model selection with robust optimization and application to maximize cell-free production of UDP-GalNAc.
Huber N, Hoang TS, Espinel Ríos S, Rexer TFT, Reichl U, Klamt S. · 2026-09-08
open access unreviewed -
2
Immunometabolism and rheumatic disease-advancing targeted therapies.
Boothby MR. · 2026-09-22
open access unreviewed -
3
Effects of dietary supplements on lower-limb power and jump performance in physically active individuals and athletes: a systematic review and Bayesian network meta-analysis.
Sun R, Su M, Xu X, Wang N, Li Z, Sun X, Lin W, Wang H. · 2026-10-01
open access unreviewed -
4
Isotopic tracing in <i>Mycobacterium tuberculosis</i>-infected alveolar epithelial cells indicates metabolic specificity to their virulence and drug-resistance status.
Akram S, Masakapalli SK, Nanda RK. · 2026-09-04
cited 1× open access unreviewed -
5
Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment.
Lin H, Deng X, Yang Y, Zhang R, Wang YD, Chen WD. · 2026-08-18
open access unreviewed -
6
Encapsulated L-Lysine: from physicochemical properties to broiler responses.
Hajati H, Ghamsari AA, Hosseini SA. · 2026-07-27
open access unreviewed -
7
Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function.
Frye RE, Rossignol DA. · 2026-08-06
open access unreviewed -
8
Isolation of Bacteria and Fungi from Human Pancreatic Tumors and Duodenum.
Awad D, Attebury H, Hong R, Kim K, Zhang L, Bischoff A, Achi S, denDekker A, Lesniak N, The S, Nieto Carrion … · 2026-07-07
open access unreviewed -
9
A senescent metabolism-modulating hierarchical scaffold restores NAD<sup>+</sup> homeostasis and redox balance for aged bone repair.
Jiang J, Chen J, Wang X, Zhang X, Lv H, Wu C, Han L, Zhu Y. · 2026-06-27
open access unreviewed -
10
The role of RNA modifications in cancer translational control.
Joy M, Cleynen A, Shirokikh NE. · 2026-07-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.