Junction / hub Pathway metabolite unreviewed

Alpha-ketoglutarate

Pathways

Reactions involving Alpha-ketoglutarate

Every recorded step where this molecule takes part

All 14 Consumed 9 Produced 5

consumed Alanine aminotransferase (ALT/GPT) Glucose-Alanine Cycle ST-0382

Alanine + alpha-ketoglutarate -> pyruvate + glutamate (liver)
consumed Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal) Amino Acid Catabolism Overview (glucogeni… ST-0146

Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
consumed Branched-chain aminotransferase (BCAT) Amino Acid Catabolism Overview (glucogeni… ST-0149

Leucine/isoleucine/valine + α-ketoglutarate ⇌ their respective branched-chain α-keto acids + glutamate
consumed Tyrosine aminotransferase (TAT) Amino Acid Catabolism Overview (glucogeni… ST-0155

L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
consumed Aminotransferase (transaminase), PLP half-reaction 2 Transamination ST-0134

E-PMP + α-ketoglutarate → E-PLP + L-glutamate
consumed Alanine aminotransferase (ALT / GPT) Transamination ST-0135

L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate
consumed Aspartate aminotransferase (AST / GOT) Transamination ST-0136

L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
consumed Branched-chain aminotransferase (BCAT) Transamination ST-0137

Branched-chain amino acid + α-ketoglutarate ⇌ branched-chain α-keto acid + L-glutamate
consumed Alpha-ketoglutarate dehydrogenase complex Citric Acid Cycle (TCA / Krebs Cycle) ST-0272

Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+

Showing all 9 reactions.

Produced in one pathway, consumed in another

14 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Glucose-Alanine Cycle	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Transamination	within category
Glucose-Alanine Cycle	→	Amino Acid Catabolism Overview (glucogenic …	cross-category
Glucose-Alanine Cycle	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Glucose-Alanine Cycle	→	Transamination	cross-category
Malate-Aspartate Shuttle	→	Amino Acid Catabolism Overview (glucogenic …	cross-category
Malate-Aspartate Shuttle	→	Citric Acid Cycle (TCA / Krebs Cycle)	within category
Malate-Aspartate Shuttle	→	Glucose-Alanine Cycle	cross-category
Malate-Aspartate Shuttle	→	Transamination	cross-category
Oxidative Deamination	→	Amino Acid Catabolism Overview (glucogenic …	within category
Oxidative Deamination	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Oxidative Deamination	→	Glucose-Alanine Cycle	cross-category
Oxidative Deamination	→	Transamination	within category

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