Acetyl-CoA
Reactions involving Acetyl-CoA
Every recorded step where this molecule takes part
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consumed (downstream fate - TCA cycle / ketogenesis; not a beta-oxidation enzyme) Beta-Oxidation of Fatty Acids ST-0081
Acetyl-CoA → CO2 in the tricarboxylic-acid cycle, or into ketogenesis in hepatic mitochondria
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
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Acetyl-CoA + oxaloacetate → citrate
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consumed Acetyl-CoA carboxylase (ACC1) Fatty Acid Synthesis (De Novo Lipogenesis) ST-0064 rate-limiting
Acetyl-CoA + HCO3− + ATP → malonyl-CoA + ADP + Pi
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consumed FAS malonyl/acetyl transferase (MAT) domain Fatty Acid Synthesis (De Novo Lipogenesis) ST-0065
Acetyl-CoA + ACP → acetyl-ACP + CoA-SH
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) + CoA-SH
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2 acetyl-CoA → 4 CO2 through two TCA-cycle turns
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Choline + acetyl-CoA -> acetylcholine + CoA-SH
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Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin
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Oxaloacetate + acetyl-CoA + H2O → citrate + CoA-SH
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
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