Choline acetyltransferase (ChAT)
Cofactors used
Clinical / pharmacological. Acetylcholine synthesis; AChE is the organophosphate target
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
Choline + acetyl-CoA -> acetylcholine + CoA-SH
Converts Choline Acetyl-CoA into Acetylcholine CoA-SH
› Notes
Hydrolysed at the synapse by acetylcholinesterase, the target of organophosphates and of anticholinesterase drugs.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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