FAS malonyl/acetyl transferase (MAT) domain
Cofactors used
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Acetyl-CoA + ACP → acetyl-ACP + CoA-SH
Converts Acetyl-CoA ACP (acyl carrier protein) into Acetyl-ACP CoA-SH
› Notes
The acetyl group is transferred by the acetyl/malonyl transferase activity of the multifunctional fatty acid synthase complex to its acyl-carrier protein (ACP) phosphopantetheine thiol; the acetyl group is then transferred to the active-site cysteine of the β-ketoacyl synthase (KS) domain. ACP contains 4′-phosphopantetheine, derived from pantothenate.
Malonyl-CoA + ACP → malonyl-ACP + CoA-SH
Converts Malonyl-CoA ACP (acyl carrier protein) into Malonyl-ACP CoA-SH
› Notes
The FAS malonyl/acetyl transferase loads malonyl-CoA onto ACP. One acetyl primer and seven malonyl units are required to make palmitate.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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