Mitochondrial thiolase (acetyl-CoA acetyltransferase, T2/ACAT1)
Cofactors used
What it does, reaction by reaction
Ketogenesis Lipid Metabolism · Liver mitochondrial matrix
2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
Converts Acetyl-CoA into Acetoacetyl-CoA CoA-SH
› Notes
Mitochondrial thiolase (acetyl-CoA acetyltransferase) condenses two acetyl-CoA molecules. This reaction is reversible and is shared conceptually with the terminal thiolysis step of β-oxidation.
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
Acetoacetyl-CoA + CoA-SH → 2 acetyl-CoA
Converts Acetoacetyl-CoA CoA-SH into Acetyl-CoA
› Notes
Mitochondrial thiolase cleaves acetoacetyl-CoA. The two acetyl-CoA molecules then enter the TCA cycle.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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