unreviewed
Cytosolic HMG-CoA synthase (HMGCS1)
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
step 2
Irreversible/directional
Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
Converts Acetoacetyl-CoA Acetyl-CoA H2O into HMG-CoA CoA-SH
› Notes
Cytosolic HMG-CoA synthase (HMGCS1) forms 3-hydroxy-3-methylglutaryl-CoA. It is distinct from mitochondrial HMGCS2 of ketogenesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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