Acetyl-CoA
Reactions involving Acetyl-CoA
Every recorded step where this molecule takes part
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consumed (downstream fate - TCA cycle / ketogenesis; not a beta-oxidation enzyme) Beta-Oxidation of Fatty Acids ST-0081
Acetyl-CoA → CO2 in the tricarboxylic-acid cycle, or into ketogenesis in hepatic mitochondria
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
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Acetyl-CoA + oxaloacetate → citrate
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consumed Acetyl-CoA carboxylase (ACC1) Fatty Acid Synthesis (De Novo Lipogenesis) ST-0064 rate-limiting
Acetyl-CoA + HCO3− + ATP → malonyl-CoA + ADP + Pi
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consumed FAS malonyl/acetyl transferase (MAT) domain Fatty Acid Synthesis (De Novo Lipogenesis) ST-0065
Acetyl-CoA + ACP → acetyl-ACP + CoA-SH
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) + CoA-SH
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2 acetyl-CoA → 4 CO2 through two TCA-cycle turns
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Choline + acetyl-CoA -> acetylcholine + CoA-SH
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Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin
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Oxaloacetate + acetyl-CoA + H2O → citrate + CoA-SH
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Characterization of two key cytochrome P450 enzymes in <i>Isodon amethystoides</i> and <i>de novo</i> production of 3α,15β-dihydroxy-<i>ent-</i>kaurene in yeast.
Chen Y, Song X, Wang Y, Han Y, Xia M, Yuan S, Ma Y, Wang J, Ma Q, Liu S, Su P, Huang L. · 2026-08-27
open access unreviewed -
2
Strategy for enhanced production of A40926B0 in <i>Nonomuraea gerenzanensis</i> using an efficient CRISPR/AsCas12f1 system.
Wang X, Zhai H, Gu D, Wang Y, Gao J, Du L, Zhuo L, Li X, Wang Y. · 2026-08-24
open access unreviewed -
3
Combinatorial metabolic engineering of <i>Mycobacterium neoaurum</i> LY-2 for efficient androstenedione production from phytosterols.
Xu L, Peng C, Pan W, Tong Y, Shi J, Xu Z, Li H. · 2026-08-19
open access unreviewed -
4
Strategies and applications for alleviating carbon catabolite repression.
Lu M, Ding H, Zhang H, Xu J, Meng R, Li Y, Zhang Z, Zheng P, Zhu Y, Sun J. · 2026-08-20
open access unreviewed -
5
Gentamicin and d-serine selective pressure to improve the homogeneity of cells expressing target proteins.
Gelain L, Yeoh JW, Au-Yeung BSY, Guillouet S, Poh CL, Gorret N, Foo JL. · 2026-08-14
open access unreviewed -
6
EINN: An enzyme-informed neural network guided by an enzyme-constrained genome-scale metabolic model.
Steven R, Kimata K, Chegodaev D, Handayani L, Satou K. · 2026-08-06
open access unreviewed -
7
Production improvement of dalbavancin precursor A40926B0 in <i>Nonomuraea gerenzanensis</i> through strain reconstruction and fermentation optimization.
Liu XY, Liu YQ, Zheng YL, Ruan JY, Fang P, Fang JL, Chen XA, Zhao QW, Lyu ZY, Li YQ. · 2026-08-03
open access unreviewed -
8
System reconstruction of <i>Bacillus licheniformis</i> for efficient expression of alkaline protease.
Zhang Q, Zhang M, Zhu Z, Ma H, Mo F, Lei J, He S, Liao Y, Yan S, Cai D, Chen S. · 2026-08-01
open access unreviewed -
9
Engineering bioactive citrate-based hydrogels for wound repair: From structure-function design to microenvironmental regulation.
Zhang L, Lei B, Zhao H. · 2026-09-08
open access unreviewed -
10
High-level amyrin production in <i>Yarrowia lipolytica</i> via metabolic and enzyme engineering.
Elsharawy H, Abdullah CN, Yin X, Zhou J. · 2026-07-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.