Acetyl-CoA
Reactions involving Acetyl-CoA
Every recorded step where this molecule takes part
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consumed (downstream fate - TCA cycle / ketogenesis; not a beta-oxidation enzyme) Beta-Oxidation of Fatty Acids ST-0081
Acetyl-CoA → CO2 in the tricarboxylic-acid cycle, or into ketogenesis in hepatic mitochondria
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
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Acetyl-CoA + oxaloacetate → citrate
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consumed Acetyl-CoA carboxylase (ACC1) Fatty Acid Synthesis (De Novo Lipogenesis) ST-0064 rate-limiting
Acetyl-CoA + HCO3− + ATP → malonyl-CoA + ADP + Pi
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consumed FAS malonyl/acetyl transferase (MAT) domain Fatty Acid Synthesis (De Novo Lipogenesis) ST-0065
Acetyl-CoA + ACP → acetyl-ACP + CoA-SH
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) + CoA-SH
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2 acetyl-CoA → 4 CO2 through two TCA-cycle turns
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Choline + acetyl-CoA -> acetylcholine + CoA-SH
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Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin
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Oxaloacetate + acetyl-CoA + H2O → citrate + CoA-SH
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Chebulinic acid suppresses NF-κB/TSLP signaling axis via ACLY-mediated lipid metabolism reprogramming to ameliorate atopic dermatitis.
Wang M, Bai Y, Guo Y, Shen X, Yang J, Miao H, Zhang X, Wang P, Kang A, Dang E. · 2026-07-16
unreviewed -
2
Degradation of ethyl carbamate by Lichtheimia ramosa EC-2 from Baijiu Daqu: Optimization, metabolites, and key enzymes.
Qin H, Guo X, Zheng J, Xu B, Lei Y, Huang X, Xie Z, Zhao D, Zhao J. · 2026-06-19
unreviewed -
3
Metabolic engineering of <i>Vibrio natriegens</i> for the efficient biosynthesis of ergothioneine from sucrose using non-sterile fed-batch fermentation.
Liang X, Wang Y, Lv Y, Huang C, Huang Z, Wei J, Jiang S, Dong Z, Zhou Z, Lin M. · 2026-06-12
open access unreviewed -
4
<i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.
Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13
open access unreviewed -
5
Multi-omics characterization of glucose-lipid metabolic remodeling associated with Gymnema sylvestre (Retz.) R.Br. ex Sm. treatment in a type 2 diabetic mouse model.
Zeng Z, Liu Y, Xiao G, Jia C, Wu M, Li Y, Jiang J, Zhang J, Xu A, Bi X. · 2026-06-20
unreviewed -
6
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
7
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
8
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
9
Systems engineering of <i>Escherichia coli</i> for high-level hydroxytyrosol production.
Zuo J, Zhang S, Huang W, Liu J, Gao C, Hu GP, Song W, Li X, Wei W, Wu J, Liu L, Liu K, Xu N. · 2026-06-01
open access unreviewed -
10
The regulatory roles of non-coding RNAs in aerobic glycolysis and therapeutic potential in pancreatic ductal adenocarcinoma.
Fan Y, Tang X, Li S, Liu S, Fang Y, Sun X, Xue Z, Niu H, Chen Y, Dai C, Ling R. · 2026-06-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.