56 pathways across 7 categories. Open any one for its full ordered reaction list, regulation table and clinical notes.
Mitochondrial β-oxidation degrades fatty acyl-CoA molecules by sequential removal of two-carbon acetyl-CoA units, producing NADH and FADH2 for oxidative phosphorylation. It predom…
Open pathwayLiver
Open pathwayCholesterol biosynthesis converts acetyl-CoA to cholesterol through the mevalonate pathway and provides precursors for steroid hormones, bile acids, vitamin D, and membrane sterol…
Open pathwayPlatelets, endothelium, leukocytes, most tissues
Open pathwayDe novo lipogenesis converts excess carbon, principally carbohydrate-derived acetyl-CoA, into fatty acids for membrane lipid synthesis, triacylglycerol storage, and production of …
Open pathwayKetogenesis converts excess hepatic mitochondrial acetyl-CoA into the water-soluble ketone bodies acetoacetate and D-β-hydroxybutyrate; acetone is a minor spontaneous breakdown pr…
Open pathwayKetolysis converts circulating acetoacetate or D-β-hydroxybutyrate into acetyl-CoA for oxidation in extrahepatic mitochondria. It is an important fuel pathway in cardiac muscle, o…
Open pathwayBecause triacylglycerols and cholesteryl esters are hydrophobic, human plasma transports them in lipoproteins: particles with a hydrophobic core and an amphipathic surface of phos…
Open pathwayAll cells; pancreas, snake/bee venoms
Open pathwayAll cells; lung type II (surfactant), liver
Open pathwayAll cells; neurons, macrophages
Open pathwayNervous tissue, all cells
Open pathway