S-adenosylmethionine (SAM)
Reactions involving S-adenosylmethionine (SAM)
Every recorded step where this molecule takes part
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consumed Phosphatidylethanolamine N-methyltransferase (PEMT) Phospholipid Synthesis (Kennedy / CDP pat… ST-0310
Phosphatidylethanolamine + 3 SAM -> phosphatidylcholine + 3 SAH
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Norepinephrine + SAM -> epinephrine + SAH
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SAM + methyl acceptor → S-adenosylhomocysteine (SAH) + methylated acceptor
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Substrate + SAM -> methylated metabolite + SAH
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L-methionine + ATP → S-adenosylmethionine (SAM) + Pᵢ + PPᵢ
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Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin
Showing all 6 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Methionine Cycle / Transmethylation (SAM Cy… | → | Catecholamine Synthesis | within category |
| Methionine Cycle / Transmethylation (SAM Cy… | → | Phase II - Conjugation | cross-category |
| Methionine Cycle / Transmethylation (SAM Cy… | → | Phospholipid Synthesis (Kennedy / CDP pathw… | cross-category |
| Serotonin & Melatonin Synthesis | → | Catecholamine Synthesis | within category |
| Serotonin & Melatonin Synthesis | → | Methionine Cycle / Transmethylation (SAM Cy… | within category |
| Serotonin & Melatonin Synthesis | → | Phase II - Conjugation | cross-category |
| Serotonin & Melatonin Synthesis | → | Phospholipid Synthesis (Kennedy / CDP pathw… | cross-category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Systematic optimization of <i>Komagataella phaffii</i> (Pichia pastoris) for high-efficiency recombinant protein production: Advancements in strain engineering, fermentation optimization, and AI-driven technologies.
Huang Y, Wang J, Wang A, Zheng L, Lin Y, Liang S. · 2026-09-11
open access unreviewed -
2
Immunometabolism and rheumatic disease-advancing targeted therapies.
Boothby MR. · 2026-09-22
open access unreviewed -
3
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Rong S, Fu Y, Li Y, Jiang YC, Chen L, Zhao Y, Zhu W, Mu L. · 2026-08-06
open access unreviewed -
4
Microbial epigenetic regulation as a multilevel regulatory interface in host-microbe interactions.
Yizengaw Adnie L, Wang GH. · 2026-08-28
open access unreviewed -
5
Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.
Fang M, Xia T, Yin Y. · 2026-08-21
open access unreviewed -
6
Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment.
Lin H, Deng X, Yang Y, Zhang R, Wang YD, Chen WD. · 2026-08-18
open access unreviewed -
7
Reconstituting a two-step pathway for <i>N</i>,<i>N</i>-dimethyltryptamine (DMT) biosynthesis in bacteria.
Junges LH, Pontes FLD, Mota FJT, Passaglia Bruschi G, Bonaldi MPF, de Souza EM, Müller-Santos M. · 2026-07-21
open access unreviewed -
8
Alternate-day fasting enhances leptin sensitivity via JMJD3-dependent epigenetic regulation of the leptin receptor in the hypothalamus.
Oladun B, Mall S, Fan B, Lee J, Ha JH, Roberts JL, Kim MH. · 2026-07-25
unreviewed -
9
p53-mediated epigenetic regulation in the pathogenesis of endometriosis.
Wang J, Liao Q, Feng X. · 2026-07-21
open access unreviewed -
10
From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis.
Kazemifard N, Shahrokh S, Dimitrov G, Totonchi M, Dimitrov S. · 2026-07-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.