Succinyl-CoA
Reactions involving Succinyl-CoA
Every recorded step where this molecule takes part
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consumed Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
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consumed Mitochondrial ALA synthase (ALAS) Heme Biosynthesis (Porphyrin Pathway) ST-0177 rate-limiting
Glycine + succinyl-CoA → δ-aminolevulinate (ALA) + CO₂ + CoA
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consumed Succinyl-CoA synthetase (succinate thiokinase) Citric Acid Cycle (TCA / Krebs Cycle) ST-0273
Succinyl-CoA + GDP + Pi ⇌ succinate + GTP + CoA-SH
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produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147
Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
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L-Methylmalonyl-CoA -> succinyl-CoA
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Propionyl-CoA → succinyl-CoA
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Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+
Showing all 7 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Metabolic profile association with white matter hyperintensity in patients with mild cognitive impairment.
Ariaei A, Zamiri R, Ghasemi A, Rezayani B, Rezayani S, Ezatpour A, Farshidi N, Sheikhi EA, Roghanian A, Alzhe… · 2026-06-09
open access unreviewed -
2
Synergistic antibacterial activity and mechanism of arginine combined with florfenicol against <i>Escherichia coli</i>.
Cao M, Li Y, Han G, Liu H, Xiong S, Liu X, Zhao M, Su Y, Li Y, Dong C. · 2026-05-04
open access unreviewed -
3
Engineering a heme-dependent tryptophan hydroxylase pathway in <i>E. coli</i> for enhanced melatonin production.
Zhang L, Yin G, Pan S, Zheng X, Zhou S, Du G, Li J, Chen J, Xu R, Kang Z. · 2026-04-11
open access unreviewed -
4
Blood metabolic profiling associated with a short-term intensive training period in elite male water polo athletes: an exploratory metabolomics study.
Sun Z, Wang L. · 2026-03-18
open access unreviewed - 5
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6
Dynamic lysine acetylation and succinylation of platelet proteins regulates platelet storage lesion: mechanistic insights from multi-omics.
Liao X, Zhang C, Chen M, Zhou J, Luo X, Zhang Y, Hu X, Wang Z, Wang L. · 2026-02-23
open access unreviewed -
7
Aberrant protein S-nitrosylation disrupts axonal development and metabolic homeostasis in a Cntnap2 mouse model of autism.
Kartawy M, Ojha SK, Nimgampalle M, Amal H. · 2026-05-28
open access unreviewed -
8
A review of the iron requirements and its determination in commercial poultry.
Morgan NK, O'Keeffe JL, Hackett MJ. · 2026-03-31
open access unreviewed -
9
Time-resolved transcriptomics reveals mechanisms of acute and sustained low-pH adaptation in <i>Corynebacterium glutamicum</i>.
Hao Y, Xu J, Sun B, Zhang H, Gu H, Wang Y, Zheng P, Jia K, Zhu Y, Sun J. · 2026-03-23
open access unreviewed -
10
Multi-omics analyses of evolved <i>Corynebacterium glutamicum</i> mutants reveal the molecular responses to formaldehyde stress.
Fan L, Cao Q, Zhang Z, Ni X, Lei Y, Shi T, Chen J, Zhang S, Zhou W, Wang Y, Zheng P, Sun J. · 2026-02-10
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.