Junction / hub Pathway metabolite unreviewed

Pyruvate

Pathways

Reactions involving Pyruvate

Every recorded step where this molecule takes part

All 12 Consumed 5 Produced 7

consumed Mitochondrial pyruvate carboxylase Gluconeogenesis ST-0016

Pyruvate + HCO3− + ATP → oxaloacetate + ADP + Pi
consumed Alanine aminotransferase (ALT/GPT) Glucose-Alanine Cycle ST-0381

Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
consumed Pyruvate dehydrogenase E1 Pyruvate Oxidation / Link Reaction (Pyruv… ST-0011

Pyruvate + thiamine pyrophosphate (TPP) → hydroxyethyl-TPP + CO2
consumed Lactate dehydrogenase (LDH) Anaerobic Glycolysis / Lactic Acid Fermen… ST-0298

Pyruvate + NADH + H+ ⇌ lactate + NAD+
consumed Pyruvate dehydrogenase E1 Pyruvate Dehydrogenase Complex (Link Reac… ST-0264

Pyruvate + TPP → hydroxyethyl-TPP + CO2

Showing all 5 reactions.

Pathway junctions through this molecule

Produced in one pathway, consumed in another

33 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Gluconeogenesis	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Glucose-Alanine Cycle	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Gluconeogenesis	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Glucose-Alanine Cycle	cross-category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Pyruvate Dehydrogenase Complex (Link Reacti…	within category
Anaerobic Glycolysis / Lactic Acid Fermenta…	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Cori Cycle (lactate shuttle)	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Cori Cycle (lactate shuttle)	→	Gluconeogenesis	within category
Cori Cycle (lactate shuttle)	→	Glucose-Alanine Cycle	within category
Cori Cycle (lactate shuttle)	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Cori Cycle (lactate shuttle)	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Gluconeogenesis	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Glucose-Alanine Cycle	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category
Glucose-Alanine Cycle	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Glucose-Alanine Cycle	→	Gluconeogenesis	within category
Glucose-Alanine Cycle	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Glucose-Alanine Cycle	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Glycolysis	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Glycolysis	→	Gluconeogenesis	within category
Glycolysis	→	Glucose-Alanine Cycle	within category
Glycolysis	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Glycolysis	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	within category
Transamination	→	Anaerobic Glycolysis / Lactic Acid Fermenta…	cross-category
Transamination	→	Gluconeogenesis	cross-category
Transamination	→	Glucose-Alanine Cycle	cross-category
Transamination	→	Pyruvate Dehydrogenase Complex (Link Reacti…	cross-category
Transamination	→	Pyruvate Oxidation / Link Reaction (Pyruvat…	cross-category

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