Acetoacetyl-CoA
Reactions involving Acetoacetyl-CoA
Every recorded step where this molecule takes part
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Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) + CoA-SH
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consumed Mitochondrial thiolase (acetyl-CoA acetyltransferase, T2/ACAT1) Ketolysis (Ketone Body Utilization) ST-0089
Acetoacetyl-CoA + CoA-SH → 2 acetyl-CoA
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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produced Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
Showing all 6 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Cholesterol Biosynthesis (Mevalonate Pathwa… | → | Ketogenesis | within category |
| Cholesterol Biosynthesis (Mevalonate Pathwa… | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketogenesis | → | Cholesterol Biosynthesis (Mevalonate Pathwa… | within category |
| Ketogenesis | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketolysis (Ketone Body Utilization) | → | Cholesterol Biosynthesis (Mevalonate Pathwa… | within category |
| Ketolysis (Ketone Body Utilization) | → | Ketogenesis | within category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Circadian reprogramming of inflammation and metabolism in chronic kidney disease.
Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06
open access unreviewed -
2
Gut microbiota and metabolic alterations in participants with flatulence identify <i>Faecalibacterium prausnitzii</i> as a key microbial target for clinical intervention.
Chen R, Zhang C, Yan S, Zhang C, Ren Y, Wang G, Cui S, Lu W, Yang B, Lyu X, Tian P, Zhao J, Tian F, Xue Y, Zh… · 2026-09-03
open access unreviewed -
3
Metabolic engineering of <i>Vibrio natriegens</i> for the efficient biosynthesis of ergothioneine from sucrose using non-sterile fed-batch fermentation.
Liang X, Wang Y, Lv Y, Huang C, Huang Z, Wei J, Jiang S, Dong Z, Zhou Z, Lin M. · 2026-06-12
open access unreviewed -
4
<i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.
Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13
open access unreviewed -
5
Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.
Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12
open access unreviewed -
6
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10
open access unreviewed -
7
Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.
Wang R, Li Z, Zhang L, Pan Y, He Z. · 2026-11-01
open access unreviewed -
8
AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies
Chen Y, Liu W, Luo B. · 2026-10-01
open access unreviewed -
9
Skeletal Muscle Fibre Type Determines Mitochondrial and Metabolic Responses to Hypoxia and Pulmonary Inflammation in Young Adult Rats.
Gavrielatos A, Cottet-Rousselle C, Brocker N, Tellier C, Achouri A, Prola A, Dubouchaud H, Chabert C. · 2026-10-01
open access unreviewed -
10
Metabolic switch: lymphocytes and the onset of T-cell-mediated autoimmunity.
Mosaffa Jahromi A, Mirzaei F, Mirzazadeh S, Meri S, Kabelitz D, Kalantar K. · 2026-08-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.