Acetoacetyl-CoA
Reactions involving Acetoacetyl-CoA
Every recorded step where this molecule takes part
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Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
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Acetoacetyl-CoA + acetyl-CoA + H2O → 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) + CoA-SH
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consumed Mitochondrial thiolase (acetyl-CoA acetyltransferase, T2/ACAT1) Ketolysis (Ketone Body Utilization) ST-0089
Acetoacetyl-CoA + CoA-SH → 2 acetyl-CoA
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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2 acetyl-CoA → acetoacetyl-CoA + CoA-SH
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produced Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
Showing all 6 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Cholesterol Biosynthesis (Mevalonate Pathwa… | → | Ketogenesis | within category |
| Cholesterol Biosynthesis (Mevalonate Pathwa… | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketogenesis | → | Cholesterol Biosynthesis (Mevalonate Pathwa… | within category |
| Ketogenesis | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketolysis (Ketone Body Utilization) | → | Cholesterol Biosynthesis (Mevalonate Pathwa… | within category |
| Ketolysis (Ketone Body Utilization) | → | Ketogenesis | within category |
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Metabolic engineering of <i>Vibrio natriegens</i> for the efficient biosynthesis of ergothioneine from sucrose using non-sterile fed-batch fermentation.
Liang X, Wang Y, Lv Y, Huang C, Huang Z, Wei J, Jiang S, Dong Z, Zhou Z, Lin M. · 2026-06-12
open access unreviewed -
2
<i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.
Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13
open access unreviewed -
3
Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.
Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12
open access unreviewed -
4
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10
open access unreviewed -
5
Beta-ketothiolase deficiency with progressive basal ganglia and extra basal ganglia involvement: CT-MRI correlation in a pediatric metabolic encephalopathy: A case report.
Gebre B, Gereziher Y, Gebrewahd D, Alcober C. · 2026-07-22
unreviewed -
6
ACAT3 controls hepatic cholesterol metabolism and modulates systemic energy homeostasis of male mice.
Ma Z, Chen Q, Zhang J, Huang Z, Wu Q, Shi T, Liu X, Shu H, Ma Y, Cheng K, Zhang C, Jia Z, Feng Y, Jiang C. · 2026-06-08
unreviewed -
7
Acetoacetyl-CoA synthetase modulates lipid partitioning and cholesterol-related gene expression in NEFA-challenged neonatal bovine hepatocytes.
Tian Y, Wang S, Loor JJ, Fan W, Chang Y, Yang T, Zhang B, Xia C, Xu C, Li X, Yang W. · 2026-05-11
unreviewed -
8
Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol in <i>Saccharomyces cerevisiae</i>.
Fu D, Zhou Y, Wu Z, Wang S, Lao Y, Wang HB, Jin HL. · 2026-02-09
cited 1× open access unreviewed -
9
Construction of a globally modular recombinant <i>Saccharomyces cerevisiae</i> chassis for ginkgolide precursor levopimaradiene production.
Liu, Chen Z, Guo Z, Xue Q, He Q, Yu R, Zhu J. · 2026-02-05
open access unreviewed -
10
Targeted identification of new phaterpenes and elucidation of the relevant biosynthetic pathway in <i>Streptomyces phaeochromogenes</i> OSK-123.
Fan X, Zhang X, Tang M, Wei S, Guo Z, Ren F, Hao J, Hua L, Zhou L, Xu J, Huang W, Kang Q, Bai L. · 2026-01-25
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.