Acetoacetate
Reactions involving Acetoacetate
Every recorded step where this molecule takes part
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Acetoacetate + NADH + H+ ⇌ D-β-hydroxybutyrate + NAD+
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Acetoacetate → acetone + CO2
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consumed Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
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HMG-CoA → acetoacetate + acetyl-CoA
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D-β-hydroxybutyrate + NAD+ → acetoacetate + NADH + H+
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produced Leucine/lysine catabolic enzyme set (purely ketogenic) Amino Acid Catabolism Overview (glucogeni… ST-0148
Ketogenic carbon skeleton → acetyl-CoA and/or acetoacetate
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Fumarylacetoacetate + H₂O → fumarate + acetoacetate
Showing all 7 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Amino Acid Catabolism Overview (glucogenic … | → | Ketogenesis | cross-category |
| Amino Acid Catabolism Overview (glucogenic … | → | Ketolysis (Ketone Body Utilization) | cross-category |
| Ketogenesis | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketolysis (Ketone Body Utilization) | → | Ketogenesis | within category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Metabolic engineering of <i>Escherichia coli</i> for efficient production of d-phenylglycine.
Xiong Y, Shang Z, Lu L, Wang T, Cai G, Shen X, Sun X, Wang J, Yuan Q. · 2026-08-07
open access unreviewed -
2
A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma.
Wen R, He G, Wan Y, Guo X, Xiong S, Wu Y, Wei Y, Li D, Lin J, Huang P. · 2026-09-16
open access unreviewed -
3
Engineering bioactive citrate-based hydrogels for wound repair: From structure-function design to microenvironmental regulation.
Zhang L, Lei B, Zhao H. · 2026-09-08
open access unreviewed -
4
Data-driven optimization of salt shock for high-efficiency ectoine production in <i>Halomonas elongata</i>.
Yu J, Gu Q, Ji S, Liu H, Zhang Y, Li C, Zhuang Y, Wang Z. · 2026-06-18
open access unreviewed -
5
Short-chain fatty acid-producing commensals: Key modulators of AD neuroinflammation via the microbiota-gut-brain axis.
Ling Z, Huang S, Cheng Y, Liu X, Xu X, Chen Y, Hu P, Wu L, Cai G. · 2026-09-10
open access unreviewed -
6
Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation.
Cheng YQ, Wei M, Yang L, Zhuang YY, Lu QB. · 2026-09-11
open access unreviewed -
7
Metabolic engineering of <i>Saccharomyces cerevisiae</i> for <i>de novo</i> biosynthesis of isoorientin.
Song Z, Zhang F, Qi X. · 2026-08-06
open access unreviewed -
8
Nutritional regulation of gut-brain immune crosstalk across the lifespan.
Zhou Y, Del Toro S, Zeng MY. · 2026-09-04
open access unreviewed -
9
Rotavirus-NSP5 interacts with and hijacks host ATP citrate lyase to viroplasms, enhancing lipid biosynthesis for facilitating rotavirus infection.
Sharma R, Banerjee S, Chaudhuri RD, Dey KK, Gope A, Miyoshi SI, Imamura D, Chawla-Sarkar M. · 2026-08-16
cited 1× open access unreviewed -
10
The ketogenic diet ameliorates behavioral abnormalities in a PTZ-induced zebrafish larvae model via modulating neurotransmitter balance.
Yang X, Lin J, Zhang Q, Xia Y, Zhou S, Wang Y, Li Q, Yu L. · 2026-08-04
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.