Acetoacetate
Reactions involving Acetoacetate
Every recorded step where this molecule takes part
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Acetoacetate + NADH + H+ ⇌ D-β-hydroxybutyrate + NAD+
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Acetoacetate → acetone + CO2
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consumed Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
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HMG-CoA → acetoacetate + acetyl-CoA
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D-β-hydroxybutyrate + NAD+ → acetoacetate + NADH + H+
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produced Leucine/lysine catabolic enzyme set (purely ketogenic) Amino Acid Catabolism Overview (glucogeni… ST-0148
Ketogenic carbon skeleton → acetyl-CoA and/or acetoacetate
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Fumarylacetoacetate + H₂O → fumarate + acetoacetate
Showing all 7 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Amino Acid Catabolism Overview (glucogenic … | → | Ketogenesis | cross-category |
| Amino Acid Catabolism Overview (glucogenic … | → | Ketolysis (Ketone Body Utilization) | cross-category |
| Ketogenesis | → | Ketolysis (Ketone Body Utilization) | within category |
| Ketolysis (Ketone Body Utilization) | → | Ketogenesis | within category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens.
DeFeo ME, Liu Y, Zhou Z, Higginbottom SK, Dodd D. · 2026-06-21
open access unreviewed -
2
Bacterial microbiome and flavor metabolome shifts in traditional Hinggan league sauerkraut fermentation.
Yang Y, Zhang H, Shuang Q, Xia YN. · 2026-06-02
open access unreviewed -
3
Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
Stanford J, Hoedt EC, Gómez-Martín M, Clarke ED, Duncanson K, Burrows T, Collins CE. · 2026-06-11
open access unreviewed -
4
Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis.
Wang W, Fortuna R, Mayengbam S, Seerattan RA, Mu C, Rios JL, Abughazaleh N, Vaghef Mehrabani E, Noye Tuplin E… · 2026-06-02
open access unreviewed -
5
A commensal protozoan exacerbates acetaminophen-induced liver injury by producing free sphingosine.
Yan X, Shen Y, Sun Q, Zhu X, Chen Q, Liao L, Zhou Y, Cheng W, Shi Z, Liu Z, Wei Y, Liu X, Wang Y, Kou Y. · 2026-06-02
open access unreviewed -
6
Explainable machine learning using urinary metabolomics to predict pediatric sepsis-associated acute kidney injury: a two-center prospective observational study.
Qian Y, Jiang Z, Miao H, Chu L, Zeng J, Fan M, Gu W, Wu M, Xu F, Ge X. · 2026-04-21
open access unreviewed -
7
Research progress of mesenchymal stem cells/stromal cells and their derivatives against cell senescence in the treatment of osteoarthritis.
Deng D, Wu Y, Wu T, Huang D, Liang X, Tan C, Li Y, Liu Y. · 2026-04-01
open access unreviewed -
8
<i>Bacteroides</i>-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity.
Huang J, Qin Q, Li X, Jiang K, Xu J, Mao Y, Kang W, Gao R, Cheng Y, Zhao W, Ke J, Mou X. · 2026-03-10
cited 2× open access unreviewed -
9
Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.
Ullah Q, Haider W, Zeshan M, Waqar M, Arshad MT, Parveen H, Mukhtar S, Zahir A. · 2026-02-10
open access unreviewed -
10
Design and optimisation of meta-substituted bis(arylsulfonamido)benzene inhibitors through a molecular hybridisation strategy targeting the Keap1-Nrf2 protein-protein interaction.
Lee S, Ali AR, Abed DA, Hu L. · 2026-02-06
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.