HMG-CoA lyase (HMGCL)
Clinical / pharmacological. HMG-CoA lyase deficiency: hypoketotic hypoglycaemia with metabolic acidosis
What it does, reaction by reaction
Ketogenesis Lipid Metabolism · Liver mitochondrial matrix
HMG-CoA → acetoacetate + acetyl-CoA
Converts HMG-CoA into Acetoacetate Acetyl-CoA
› Notes
HMG-CoA lyase cleaves HMG-CoA to the first ketone body, acetoacetate, and acetyl-CoA. No nucleotide cofactor is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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