Leucine/lysine catabolic enzyme set (purely ketogenic)
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Ketogenic carbon skeleton → acetyl-CoA and/or acetoacetate
Converts Amino acid carbon skeleton (ketogenic) into Acetyl-CoA Acetoacetate
› Notes
Leucine and lysine are exclusively ketogenic; their carbon is converted to acetyl-CoA, acetoacetate, or acetoacetyl-CoA. Isoleucine, phenylalanine, tyrosine, tryptophan, and threonine produce both ketogenic and glucogenic products; acetyl-CoA cannot yield net glucose because both of its carbons are lost as CO₂ during TCA-cycle turnover.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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