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Junction / hub Pathway metabolite unreviewed

Tetrahydrofolate (THF)

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Pathways
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Categories
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As substrate
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As product
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Reactions involving Tetrahydrofolate (THF)

Every recorded step where this molecule takes part

All 10 Consumed 3 Produced 7

Showing all 10 reactions.

Pathway junctions through this molecule

Produced in one pathway, consumed in another

6 links
Produced in Consumed in Link
Deoxyribonucleotide Formation (Ribonucleoti… → One-Carbon Metabolism (Folate Cycle) cross-category
Methionine Cycle / Transmethylation (SAM Cy… → Deoxyribonucleotide Formation (Ribonucleoti… cross-category
Methionine Cycle / Transmethylation (SAM Cy… → One-Carbon Metabolism (Folate Cycle) within category
One-Carbon Metabolism (Folate Cycle) → Deoxyribonucleotide Formation (Ribonucleoti… cross-category
Pyrimidine De Novo Synthesis (through to UM… → Deoxyribonucleotide Formation (Ribonucleoti… within category
Pyrimidine De Novo Synthesis (through to UM… → One-Carbon Metabolism (Folate Cycle) cross-category

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Comprehensive safety assessment of novel dicholine folate vitamin.

    Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15

    open access unreviewed
  2. 2
    Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.

    Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24

    open access unreviewed
  3. 3
    Interactions between nutrition and the epigenome: how can it be harnessed for public health?

    Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12

    cited 2× open access unreviewed
  4. 4
    Folate transporters at the plasma membrane of fungi and plants: specificity, mechanism of transport, and importance

    Vashist N, Bachhawat A. · 2026-10-01

    open access unreviewed
  5. 5
    Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.

    Fustin JM. · 2026-10-01

    open access unreviewed
  6. 6
    Oligomeric defects in soybean serine hydroxymethyltransferase 8: tetramer destabilization by A149T and other variants associated with soybean cyst nematode resistance.

    Samarakoon V, Buckley DP, Owuocha LF, Durie CL, Mitchum MG, Beamer LJ. · 2026-03-31

    unreviewed
  7. 7
    Bifunctional architecture enables substrate catalysis and channeling in <i>Paracoccus</i> TMAO demethylase.

    Thach T, Dhanabalan K, Maurya S, Han-Hallett Y, Quan S, Allison J, Ramanathan G, Subramanian R. · 2026-09-28

    open access unreviewed
  8. 8
    Diet-Induced Hyperhomocysteinemia in C57BL/6 Mice: Simultaneous Evaluation of Plasma Homocysteine, Methionine, and Cysteine by LC-MS/MS and Assessment of Associated Oxidative Stress in Brain Homogenates.

    Valle ML, De Jesus CL, Getaneh B, Erdjument-Bromage H, Loveland J, William C, Arienzo D, Neubert TA, Rostagno… · 2026-09-11

    open access unreviewed
  9. 9
    Mitochondrial NADP(H)-dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors.

    Li Q, Shu T, Liu C, Zheng M, Li Y, Zhang L, Fan G, Lu W, Zhang H, Liu P, He X, Zheng H, Liu W, Ye J, Yin Z, D… · 2026-09-24

    open access unreviewed
  10. 10
    Folate: An Emerging Target in Type 2 Diabetes Mellitus and Its Complications.

    Xiao X, Qin S, Jiang Z, Huo Y, Li J, Yang M. · 2026-09-17

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.