Tetrahydrofolate (THF)
Reactions involving Tetrahydrofolate (THF)
Every recorded step where this molecule takes part
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L-serine + THF ⇌ glycine + 5,10-methylene-THF + H₂O
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THF + formate + ATP ⇌ 10-formyl-THF + ADP + Pᵢ
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consumed Serine hydroxymethyltransferase (SHMT1/SHMT2) Deoxyribonucleotide Formation (Ribonucleo… ST-0259
THF → 5,10-methylene-THF
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Homocysteine + 5-methyl-THF → methionine + THF
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Dihydrofolate (DHF) + NADPH + H⁺ → tetrahydrofolate (THF) + NADP⁺
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10-Formyl-THF + glycinamide ribonucleotide (GAR) → formyl-GAR + THF
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10-Formyl-THF + AICAR → formyl-AICAR + THF
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5-Methyl-THF + homocysteine → THF + methionine
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DHF → THF
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DHF → THF; THF → 5,10-methylene-THF
Showing all 10 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Deoxyribonucleotide Formation (Ribonucleoti… | → | One-Carbon Metabolism (Folate Cycle) | cross-category |
| Methionine Cycle / Transmethylation (SAM Cy… | → | Deoxyribonucleotide Formation (Ribonucleoti… | cross-category |
| Methionine Cycle / Transmethylation (SAM Cy… | → | One-Carbon Metabolism (Folate Cycle) | within category |
| One-Carbon Metabolism (Folate Cycle) | → | Deoxyribonucleotide Formation (Ribonucleoti… | cross-category |
| Pyrimidine De Novo Synthesis (through to UM… | → | Deoxyribonucleotide Formation (Ribonucleoti… | within category |
| Pyrimidine De Novo Synthesis (through to UM… | → | One-Carbon Metabolism (Folate Cycle) | cross-category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24
open access unreviewed -
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
open access unreviewed -
3
Liposomes containing histidine overcome poly ADP-ribose polymerase inhibitor resistance.
Zhang J, Tufail M, Deng Y, Ling HJ, Peng L, Wu J, Zeng, Zhang Y, He L, Peng H, Afzal A, Sun Y, Gao X, Li J. · 2026-06-05
unreviewed -
4
Kinetic-Gated Signal Transduction Decouples Binding Affinity in a Dual-Pocket Riboswitch RNA.
Chen D, Liu Y. · 2026-08-09
unreviewed -
5
Comparative binding and activity analysis of known serine hydroxymethyltransferase inhibitors in biochemical assays.
Gräb J, Wagner C, Beber C, Szczesny J, Rubner S, Papasotiriou I. · 2026-07-02
unreviewed -
6
Folate profile in frontal cortex from male human infant decedents.
Kuchan MJ, Ehling S, Draher JR. · 2026-05-12
unreviewed -
7
Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes.
Nel L, Driller JH, Driller R, Frain KM, Pedersen BP. · 2026-05-11
open access unreviewed -
8
Interplays and functional divergences of one-carbon metabolic shunts.
Wang Z, Yu W, Wang D. · 2026-03-26
unreviewed -
9
[Metabolic engineering of <i>Escherichia coli</i> for l- threonine synthesis with glucose and formate as co-substrates].
Wang Z, Liang G, Wang J, Gao C, Liu J, Wu J. · 2026-06-01
unreviewed -
10
The impact of vitamin B12 deficiency on urinary profile of <i>de novo</i> purine synthesis intermediates: consequences of the methylfolate trap.
Krijt J, Škopová V, Sokolová J, Zikánová M, Chrastina P, Stanovský S, Kožich V. · 2026-06-24
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.