GAR transformylase (GART)
Cofactors used
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
10-Formyl-THF + glycinamide ribonucleotide (GAR) → formyl-GAR + THF
Converts 10-Formyl-THF Glycinamide ribonucleotide (GAR) into Formylglycinamide ribonucleotide (FGAR) Tetrahydrofolate (THF)
› Notes
GAR transformylase (the phosphoribosylglycinamide formyltransferase domain of GART) donates one formyl group during de novo purine synthesis. This reaction is a committed folate-dependent input into the purine pathway after early purine assembly has begun.
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
GAR → formylglycinamide ribonucleotide (FGAR)
Converts Glycinamide ribonucleotide (GAR) into Formylglycinamide ribonucleotide (FGAR)
› Notes
GAR transformylase transfers a formyl group: GAR + 10-formyl-THF → FGAR + THF. This is the first of two folate-dependent one-carbon transfer steps and introduces C8 of the purine ring.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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