unreviewed
10-Formyl-THF synthetase
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
step 5
Irreversible
THF + formate + ATP ⇌ 10-formyl-THF + ADP + Pᵢ
Converts Tetrahydrofolate (THF) Formate ATP into 10-Formyl-THF ADP Pi
› Notes
10-Formyl-THF synthetase activity of MTHFD1 activates formate onto THF. ATP is consumed; in the direction of formate incorporation this is an essentially irreversible, energy-coupled reaction.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
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