unreviewed

AICAR transformylase (ATIC)

2 reactions · 2 pathways

Cofactors used

THF (folate) · B9 (Folate)

What it does, reaction by reaction

2 reactions

One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 8 Irreversible/directional

10-Formyl-THF + AICAR → formyl-AICAR + THF

Converts 10-Formyl-THF AICAR into FAICAR Tetrahydrofolate (THF)

› Notes

AICAR transformylase (ATIC) donates the second formyl group required for inosine monophosphate synthesis. This reaction is followed by cyclization to IMP by the IMP cyclohydrolase activity of ATIC.

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 10 Irreversible/directional

AICAR → 5-formamidoimidazole-4-carboxamide ribonucleotide (FAICAR)

Converts AICAR into FAICAR

› Notes

AICAR transformylase catalyzes AICAR + 10-formyl-THF → FAICAR + THF. The donated formyl carbon becomes C2 of the purine ring.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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