Serine hydroxymethyltransferase (SHMT1/SHMT2)
Cofactors used
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
L-serine + THF ⇌ glycine + 5,10-methylene-THF + H₂O
Converts Serine Tetrahydrofolate (THF) into Glycine 5,10-Methylene-THF H2O
› Notes
Serine hydroxymethyltransferase (SHMT1 cytosolic; SHMT2 mitochondrial) uses PLP (vitamin B6) to transfer the serine β-carbon to THF. This reversible reaction is a major source of 5,10-methylene-THF.
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
THF → 5,10-methylene-THF
Converts Tetrahydrofolate (THF) into 5,10-Methylene-THF
› Notes
Serine hydroxymethyltransferase (SHMT) catalyzes serine + THF ⇌ glycine + 5,10-methylene-THF, requiring pyridoxal phosphate. The folate-bound one-carbon unit can also be supplied through the cytosolic mitochondrial one-carbon network; adequate folate metabolism is required to sustain this step.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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