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unreviewed

Squalene monooxygenase (squalene epoxidase)

1 reactions · 1 pathways

Cofactors used

FAD · B2 (Riboflavin) H2O NADP+ · B3 (Niacin) NADPH · B3 (Niacin) O2

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 12 Irreversible/directional

Squalene + O2 + NADPH + H+ → (S)-2,3-oxidosqualene + NADP+ + H2O

Converts Squalene O2 NADPH H+ into (S)-2,3-Oxidosqualene NADP+ H2O

› Notes

Squalene monooxygenase (squalene epoxidase), an FAD-dependent ER monooxygenase, uses NADPH and oxygen to form the epoxide. This is an important secondary regulatory point.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Cholesterol Biosynthesis (Mevalonate Pathway)

Listed there as: Squalene monooxygenase

Accelerated by

Low cholesterol; increased substrate squalene

Inhibited by

Cholesterol-dependent degradation

Hormonal control

Responds predominantly to sterol-dependent proteostasis, with indirect insulin/feeding effects

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    High-level amyrin production in <i>Yarrowia lipolytica</i> via metabolic and enzyme engineering.

    Elsharawy H, Abdullah CN, Yin X, Zhou J. · 2026-07-15

    unreviewed
  2. 2
    Research progress of ferroptosis in gynecological diseases.

    Chen W, Zhou W, Liu S. · 2026-06-19

    open access unreviewed
  3. 3
    Recalcitrant tinea infections due to <i>Trichophyton indotineae</i> in the United States (2025-2026): a retrospective case series identified by real-time PCR.

    Gupta AK, Wang T, Lincoln SA, Bakotic WL. · 2026-05-06

    cited 1× unreviewed
  4. 4
    Molecular mechanisms of folliculogenesis and oogenesis.

    Ezz MA, Balboula AZ. · 2026-04-02

    cited 1× open access unreviewed
  5. 5
    The complex subunit VdAP-2α regulates polar growth, ergosterol metabolism, and virulence in <i>Verticillium dahliae</i>.

    Wang YH, Zhu D, Wang D, Sheng RC, Wang LC, Zhang CN, Latif MF, Li H, Chen FM. · 2026-03-24

    cited 1× open access unreviewed
  6. 6
    Multi-target protective effects of <i>Agrimonia pilosa</i> Ledeb. against metabolic dysfunction-associated steatohepatitis in mice.

    Fu X, You J, Yang Y, Qi S, Yang S, Qu X, Shao Y, Wang N, Wang Z, Li Y, Zheng M, Yang H, Zhao J, He X, He Y. · 2026-03-09

    open access unreviewed
  7. 7
    Research on tissue-resident macrophages in the field of cancer research: a bibliometric analysis from 2004 to 2025.

    Song Q, Yu Z, Lu W, Chi Q. · 2026-02-02

    open access unreviewed
  8. 8
    Infantile tinea faciei caused by Trichophyton indotineae successfully treated with topical ketoconazole: A case report.

    Nguyen Hoang C, Pham Thi Thanh V, Tang Tuan H, Pham Huy K, Phan Minh T, Ton Nu PA, Ngo TMC. · 2026-06-02

    unreviewed
  9. 9
    Impacts of underwater low-frequency noise during the operational phase of offshore wind farms on juvenile black scraper (Thamnaconus modestus).

    Song S, Shan X. · 2026-06-09

    unreviewed
  10. 10
    8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism.

    Liu J, Zhao Y, Gong X, Yuan L, Yang S, Jian W, Yan H, Chen H, Yang Z, Sun Y, Gu T, Lu H, Zhao H, Tu Z. · 2025-09-26

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.