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unreviewed

Squalene monooxygenase (squalene epoxidase)

1 reactions · 1 pathways

Cofactors used

FAD · B2 (Riboflavin) H2O NADP+ · B3 (Niacin) NADPH · B3 (Niacin) O2

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 12 Irreversible/directional

Squalene + O2 + NADPH + H+ → (S)-2,3-oxidosqualene + NADP+ + H2O

Converts Squalene O2 NADPH H+ into (S)-2,3-Oxidosqualene NADP+ H2O

› Notes

Squalene monooxygenase (squalene epoxidase), an FAD-dependent ER monooxygenase, uses NADPH and oxygen to form the epoxide. This is an important secondary regulatory point.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Cholesterol Biosynthesis (Mevalonate Pathway)

Listed there as: Squalene monooxygenase

Accelerated by

Low cholesterol; increased substrate squalene

Inhibited by

Cholesterol-dependent degradation

Hormonal control

Responds predominantly to sterol-dependent proteostasis, with indirect insulin/feeding effects

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    High-level amyrin production in <i>Yarrowia lipolytica</i> via metabolic and enzyme engineering.

    Elsharawy H, Abdullah CN, Yin X, Zhou J. · 2026-07-15

    open access unreviewed
  2. 2
    Systematic enzyme and cofactor engineering for efficient ursolic acid biosynthesis in <i>Yarrowia lipolytica</i>.

    Elsharawy H, He Q, Zeng W, Zhou J. · 2026-07-17

    open access unreviewed
  3. 3
    Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.

    He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H. · 2026-06-19

    open access unreviewed
  4. 4
    Functional characterization of SHC-like triterpene cyclase genes in azole response and virulence-related traits of <i>Aspergillus fumigatus</i>.

    Ye K, Chen F, Hu L, Han J, Li D, Hu M, Wang C, Zeng J, Han L. · 2026-09-05

    cited 1× open access unreviewed
  5. 5
    HSV-1 metabolic hijacking: Mechanisms to precision therapeutics.

    Kuang S, Zhang J, Chen J, He Z, Yang J, Li S, Ding J, Ma Z, Zhang B. · 2026-08-11

    open access unreviewed
  6. 6
    Non-coding RNAs in dermatophytosis: Key regulators of host-fungal interactions and pathogenesis-A review.

    Wan J, Zhu X, Zheng J, Li B, Zhang R, Zang F, Hu Y, Chen Y, Wang Z, Yang K, Zhang C, Xiao W. · 2026-08-09

    open access unreviewed
  7. 7
    Research progress of ferroptosis in gynecological diseases.

    Chen W, Zhou W, Liu S. · 2026-06-19

    open access unreviewed
  8. 8
    Recalcitrant tinea infections due to <i>Trichophyton indotineae</i> in the United States (2025-2026): a retrospective case series identified by real-time PCR.

    Gupta AK, Wang T, Lincoln SA, Bakotic WL. · 2026-05-06

    cited 1× unreviewed
  9. 9
    Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant <i>Paris polyphylla</i>.

    Subthain H, Guo F, Zhang C, Fang P, Zhang L, Su Q, Tang D, Chi L, Liu C, Urlacher VB, Li J, Du L, Li S. · 2026-04-21

    open access unreviewed
  10. 10
    Molecular mechanisms of folliculogenesis and oogenesis.

    Ezz MA, Balboula AZ. · 2026-04-02

    cited 4× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.